SERPINS2019

Seville 19-22 September

Venue: Meliá Sevilla

Organising Committee
Marie-Christine Bouton, Javier Corral, James Huntington, James Whisstock and Lakshmi Wijeyewickrema

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Welcome

The SERPINS2019 Conference will be taking place in stunning Seville at the Meliá Sevilla Hotel.


Thank you to our sponsors:

Agenda

Day 1 (19 Sept)

12:00 - 18:00 Registration
17:00 Welcome

Jim Huntington (Chair)

17:15 - 18:00 Plenary

Robin Carrell: ‘A brief history of the ROBINs’

18:00 - 19:30 Session 1

Serpin Structure, Folding and Evolution

  • Unifying the Serpin phylogeny: relationships in protein sequence, structure and function – Matthew Spence
  • Angiotensinogen-Renin Structures- Aiwu Zhou
  • Structural basis for inhibition by miropin, a bacterial serpin form the periodontopathogen Tannerella forsythia – Xavier Gomez Ruth
19:30 Drinks Reception

Day 2 (20 Sept)

09:00 - 10:30 Session 2

Antitrypsin Deficiency- Causes and Treatments

  • Conformation-specific monoclonal antibodies against α1-antitrypsin to investigate its physiological and pathological roles – Elena Miranda
  • Z-specific small molecule folding correctors – Jim Huntington
  • TBD
10:30 - 11:00 Coffee break

Group Photo

11:00 - 12:30 Session 3

Serpins and Thrombosis

  • Increasing the specificity of α1-PI for factor XIa– William Sheffield
  • TBD
  • TBD
12:30 - 14:00 Lunch
14:00 - 15:30 Session 4

Serpins and Haemophilia

  • Fitusiran – TBD
  • APC inhibition by SerpinPC – Trevor Baglin
  • PN-1 KO rescues bleeding in haemophilia mice – Marie-Christine Bouton
15:30 - 16:00 Coffee break
16:30 - 17:30 Session 5

HAE: C1-inhibitor and more 

  • Modified α1-antitrypsin to inhibit thromboinflammation  – Coen Maas (SerpinX)
  • TBD
  • TBD
17:30 - 19:30 Poster Session

Day 3 (21 Sept)

09:00 - 10:30 Session 6

The many faces of PAI-1 in health and disease

  • PAI-1 deficiency contributes to major depressive disorders – Denis Vivien
  • Development of an orally active small molecule inhibitor of PAI-1 for the treatment of fibrotic disease – Dan Lawrence
  • TBD
10:30 - 11:00 Coffee break
11:00 - 12:30 Session 7

Serpins and Inflammation

  • The role of protein Z-dependent protease inhibitor (ZPI) at the interface between coagulation and inflammation – Elsa Bianchini
  • SerpinB1 and SerpinB6 inhibit inflammation by controlling gasdermin D activation by cathepsin G – Charaf Benarafa
  • An unexpected role for SerpinB1 in regulating glucose homeostasis – Rohit Kulkarni
12:30-14:00 Lunch
14:00-15:30 Session 8

Hot Topics (selected from abstracts)

15:30 - 16:00 Coffee break
16:00 - 17:30 Session 9

Parasites and pathogens

  • Miropin: the Yin and Yang of Tannerella forsythia pathogenicity – Jan Potempa
  • Modulation of haemostatic mechanisms in bacterial infectious diseases – Heiko Herwald
  • The role of tick salivary serpins in the modulation of host immune system – Jindřich Chmelař
17:30 - 18:00 Serpin Site

Selection of next Serpin Site

19:00 Gala Dinner

Contact

Mon-Fri 0900-1700 UK time

Telephone:
+44 116 230 2040

Email:
serpins@sjevents.co.uk