SERPINS2019

Seville 19-22 September

Venue: Meliá Sevilla

Organising Committee
Marie-Christine Bouton, Javier Corral, James Huntington, James Whisstock and Lakshmi Wijeyewickrema

Register Now

Welcome

The SERPINS2019 Conference will be taking place in stunning Seville at the Meliá Sevilla Hotel.

Places for this fantastic conference are filling fast and we are really looking forward to welcoming you all to Sevilla! We have been asked to extend the early bird offer until Friday 16th August to allow anyone currently on vacation to secure a place at the early bird price. Please note that we have a strictly limited number of rooms still available at the hotel so please confirm your registration now to avoid disappointment.

Additionally we have extended the deadline for abstract submissions to 25th August. Register now to secure your place and avoid disappointment.


Thank you to our sponsors:

Agenda

Day 1 (19 Sept)

12:00 - 18:00 Registration
17:00 Welcome

Jim Huntington

17:15 - 18:00 Plenary

The Story of the Serpins
Robin Carrell

18:00 - 19:30 Session 1

Serpin Structure, Folding and Evolution
James Whisstock (Chair)

18:00 - 18:30 Session 1

Unifying the Serpin phylogeny: relationships in protein sequence, structure and function
Matthew Spence

18:30 - 19:00 Session 1

Angiotensinogen-Renin Structures
Aiwu Zhou

19:00 - 19:30 Session 1

Structural basis for inhibition by miropin, a bacterial serpin form the periodontopathogen Tannerella forsythia
Xavier Gomez Ruth

19:30 Drinks Reception

Day 2 (20 Sept)

09:00 - 10:30 Session 2

Antitrypsin Deficiency- Causes and Treatments
Elena Miranda (Chair)

09:00 - 9:30 Session 2

Conformation-specific monoclonal antibodies against α1-antitrypsin to investigate its physiological and pathological roles
Elena Miranda

9:30-10:00 Session 2

Z-specific small molecule folding correctors
Jim Huntington

10:00 - 10:15  Session 2

Computational and Experimental Investigations of Local Folding in Alpha-1 Antitrypsin
Patrick Wintrode

10:15 - 10:30 Session 2 (4 of 4)

Drug discovery using C. elegans model of 1-antitrypsin deficiency identifies novel compounds that enhance autophagic flux
Stephen Pak

10:30 - 11:00 Coffee break

Group Photo

11:00 - 12:30 Session 3

Serpins and Thrombosis
Paul Declerck (Chair)

11:00 - 11:30  Session 3

Increasing the specificity of α1-PI for factor XIa
William Sheffield

11:30 - 12:00 Session 3

What nature teaches about antithrombin deficiency
Javier Corral

12:00 - 12:15  Session 3

The role of Plasminogen Activator Inhibitor Type -2 (PAI-2) in modulating venous thrombus resolution
Toni Antalis

12:15 - 12:30 Session 3

Structure-Function Analysis of the N-terminal Tail of Heparin Cofactor II
Ingrid Verhamme

12:30 - 14:00 Lunch
14:00 - 15:30 Session 4

Serpins and Haemophilia
Robin Carrell (Chair)

14:00 - 14:30  Session 4

APC inhibition by SerpinPC
Trevor Baglin

14:30 - 15:00  Session 4

PN-1 KO rescues bleeding in haemophilia mice
Marie-Christine Bouton

15:00 - 15:15  Session 4

Recognition of Misfolded Antithrombin III by Endoplasmic Reticulum Quality Control is Thiol-Dependent
Anne Gershenson

15:15 - 15:30 Session 4

Intracellular functions of SERPINA5 (protein C inhibitor, PCI)
Margarethe Geiger

15:30 - 16:00 Coffee break
16:00 - 17:30 Session 5

Serpins and Inflammation
Margarethe Geiger (Chair)

16:00-16:30  Session 5

Modified α1-antitrypsin to inhibit thromboinflammation
Coen Maas

16:30 - 17:00 

The role of protein Z-dependent protease inhibitor (ZPI) at the interface between coagulation and inflammation
Elsa Bianchini

17:00 - 17:15

Modulation of Serpin B1 Function(s) by Oxidation
Philip Pemberton

17:15 - 17:30

Serine protease inhibitors from gut microbiota acting on human proteases involved in inflammatory bowel diseases
Moez Rhimi

17:30 - 19:30 Poster Session

Day 3 (21 Sept)

09:00 - 10:30  Session 6

The many faces of PAI-1 in health and disease
Toni Antalis (Chair)

9:00 - 9:30   Session 6

PAI-1 deficiency contributes to major depressive disorders
Denis Vivien

9:30 - 10:00   Session 6

Development of an orally active small molecule inhibitor of PAI-1 for the treatment of fibrotic disease
Dan Lawrence

10:00 - 10:15  Session 6

High-throughput quantitative characterization of PAI-1 mutational landscape
Laura Haynes

10:15 - 10:30  Session 6

Implication of plasminogen activation system in multiple sclerosis animal models
H Lebas

10:30 - 11:00 Coffee break
11:00 - 12:30 Session 7

Plan B Serpins
Laksmi Wijeyewickrema (Chair)

11:00 - 11:30 Session 7

SerpinB1 and SerpinB6 inhibit inflammation by controlling gasdermin D activation by cathepsin G
Charaf Benarafa

11:30 - 12:00  Session 7

An unexpected role for SerpinB1 in regulating glucose homeostasis
Rohit Kulkarni

12:00 - 12:15 Session 7

Inhibition of serpinB13 stimulates beta-cell development via Notch signalling pathway and delays progression to insulin-dependent diabetes
Jan Czyzyk

12:15 - 12:30  Session 7

Serpin6b inhibits Granzyme A-mediated macrophage inflammatory response and improves sepsis and inflammatory colorectal cancer
Llipsy Santiago

12:30 - 14:00 Lunch
14:00 - 15:30 Session 8

Hot Topics
Ian Smith (Chair)

14:00 - 14:15 Session 8

Receptor-mediated internalization of SERPINA12 (vaspin) into adipocytes
John Heiker

14:15 - 14:30  Session 8

Lysoptosis: an ancient lysosomal-mediated cell death pathway regulated by intracellular cysteine protease inhibitory serpins
Cliff Luke

14:30 - 14:45  Session 8

Viral serpin-mediated immune protection in a lethal mouse gammaherpesviral infection is dependent on the gut microbiome
Jordan Yaron

14:45 - 15:00  Session 8

Borrelia burgdorferi infection responsive serpins in Ixodes scapularis
Albert Mulenga

15:00 - 15:15  Session 8

Elucidation of the molecular mechanisms of nanobodies that neutralize plasminogen activator inhibitor 1 (PAI-1) activity highlights their versatility in modulating various stages in the PAI-1/plasminogen activator (PA) interaction
Machteld Sillen

15:15 - 15:30  Session 8

Neuroserpin as a key player in hippocampal development and plasticity
Giovanna Galliciotti

15:30 - 16:00 Coffee break
16:00 - 17:30 Session 9

Parasites and pathogens
Jan Potempa (Chair)

16:00 - 16:30 Session 9

Miropin: the Yin and Yang of Tannerella forsythia pathogenicity
Jan Potempa

16:30 - 17:00 Session 9

Modulation of haemostatic mechanisms in bacterial infectious diseases
Heiko Herwald

17:00 - 17:30 

The role of tick salivary serpins in the modulation of host immune system
Jindřich Chmelař

17:30 - 18:00 Serpin Site

Selection of next Serpin Site

19:30 Gala Dinner

Contact

Mon-Fri 0900-1700 UK time

Telephone:
+44 116 230 2040

Email:
serpins@sjevents.co.uk